Introduction: Thalassemia which is also called Cooley__ampersandsignrsquo;s anaemia or Mediterranean anaemia is a group of hereditary hemolytic anaemia characterized by a reduction in the synthesis of haemoglobin. The word __ampersandsignlsquo;thalassemia__ampersandsignrsquo; is derived from the Greek word __ampersandsignlsquo;Thalassa__ampersandsignrsquo; which means the great sea. Clinical observations: Abdominal pain, fever (Temperature - 101?F), Anemia (Hb __ampersandsignndash; 6.4gm%). Diagnostic evaluation: Hb% __ampersandsignndash; 6.4gm%, Total RBC count __ampersandsignndash; 2.3 millions/cu.mm, RDW __ampersandsignndash; 18.2%, HCT __ampersandsignndash; 20.2%, Total WBC count __ampersandsignndash; 3200/cu.mm, Monocytes __ampersandsignndash; 02%, Granulocytes __ampersandsignndash; 20%, Lymphocytes __ampersandsignndash; 77%, AST(SGOT) __ampersandsignndash; 112 U/L. Peripheral Smear: RBC __ampersandsignndash; mild hypochromic with mild cystosis which show few microcytic and mildly hypochromic. Platelets __ampersandsignndash; Reduced on smear, APC __ampersandsignndash; 62,000 cells. Ultrasonography: Splenomegaly. Therapeutic interventions: Blood transfusion, Inj. Cefotaxime 750mg IV x BD, Syr. Azee 4ml x OD, Tab. Folic Acid 5mg x OD, Tab. Udiliv 150mg x BD, Cap. Hydra 500mg x OD, Tab. Prednisolone 10mg x BD. Outcome: After treatment, the child show improvement. His fever and abdominal pain were relieved and his Hb% increased from 6.4gm% to 11gm% after blood transfusion. Conclusion: My patient was admitted to Pediatric Ward No __ampersandsignndash; 14, AVBRH with a known case of Thalassemia and he had a com plaint of fever and abdominal pain. After getting appropriate treatment his condition was improved.