IJCRRI Journ Cur Res ReInternational Journal of Current Research and ReviewI Journ Cur Res Re2231-21960975-5241Radiance Research Academy3497 http://dx.doi.org/10.31782/IJCRR.2021.13601HealthcaremRNA Expression of Somatostatin Receptors (1-5) in MCF7 and MDA-MB231 Breast Cancer Cells MahmoudAlkhansaMancusoMaria TeresaTannoBarbaraBakarMd Zuki AbuHamzahHazilawatiNoorMohd Hezmee Mohd20032021)913This article is copyright of Popeye Publishing, 20092009This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.

Background: Breast cancer is one of the most common types of cancer and heterogeneous disease. Somatostatin receptors (SSTRs) are expressed in normal and tumour tissues including breast cancer cells. Objective: The aim of this study to evaluate the expression of SSTRs subtypes 1 __ampersandsignndash; 5 in MCF7 and MDA-MB231 human breast cancer cell lines and compare the levels between two cells. Methods: The detection of mRNA expression levels of SSTRs in MCF7 and MDA-MB231 was performed using quantitative polymerase chain reaction (qPCR). Results: SSTR1, 2, 3 and 4 mRNA levels were significantly higher in MDA-MB-231 about MCF-7. The expression of SSTR 4 mRNA was highest in MDA-MB231 and MCF-7 cell lines, however, SSTR3 mRNA was least expressed in both cell lines. Conclusion: SSTRs subtypes (1 __ampersandsignndash; 5) were expressed in both MDA-MB231 and MCF7 cells. However, the levels of expression differ between both cell lines.

Breast cancer Cell lines Somatostatin receptors and mRNA expression