Introduction: Hypothyroidism is the second most prevalent endocrinal disorder in India. Most of existing data supports that thyroid disease is associated with increased cardiovascular risk which is mainly attributed to hemodynamic alteration as well as to a high risk of atherosclerosis, dylipidemia and insulin resistance. Aim: To investigate relationship between thyroid function and biochemical risk factors of cardiovascular diseases. Material and Methods: The present study was a cross-sectional, prospective. The study population was comprised of a total of ninety (90) participants (30 new cases of overt hypothyroidism, 30 new cases of subclinical hypothyroidism and 30 age and gender matched controls). Estimation of serum Thyroid profile and Insulin (fT3 , fT4 and TSH) was done by CLIA while Glucose and Lipid profile were estimated by biochemistry autoanalyzer. Insulin Resistance was calculated by HOMA IR score. Statistical Analysis: Data obtained was statistically analyzed by using student __ampersandsignldquo;t__ampersandsignrdquo; test. Results: We found statistically significant rise in the levels of serum cholesterol triglycerides VLDL and LDL in the cases of overt hypothyroidism than controls. HDL levels are low in overt hypothyroidism. We also found statistically significant rise in the levels of blood glucose, serum insulin and HOMA IR score in cases of overt hypothyroidism than controls. Conclusion: Overt Hypothyroidism is at the risk of developing cardiovascular diseases and type II DM.