Introduction: Different methods, including the Ranson criteria, Acute Physiology __ampersandsignamp; Chronic Health Assessment (APACHE) II, Computed Tomography (CT) Severity Index (CTSI), Glasgow __ampersandsignamp; Imrie scoring systems, have been used over the years to predict the severity and outcome of acute pancreatitis. Each has benefits __ampersandsignamp; drawbacks __ampersandsignamp; none of them is currently accepted as a standard criterion. An early, easy, clear, reliable __ampersandsignamp; reproducible definition of disease severity could promise an ideal scoring system. Objective: To evaluate the efficacy of BISAP __ampersandsignamp; APACHAE2 Scoring System in early prediction of severity in Acute Pancreatitis. Methods: A total of 50 consecutive cases fulfilling the eligibility criteria were taken for study after informed consent. Results: The BISAP score__ampersandsignrsquo;s sensitivity __ampersandsignamp; specificity was 75% __ampersandsignamp; 76.2%, with a positive __ampersandsignamp; negative predictive value of 37.5% __ampersandsignamp; 94.1%. The overall accuracy of the BISAP score for extreme acute pancreatitis prediction was 76%. The APACHE II score__ampersandsignrsquo;s sensitivity __ampersandsignamp; specificity was 62.5% __ampersandsignamp; 85.7%, with a positive __ampersandsignamp; negative predictive value of 45.5% __ampersandsignamp; 92.3%. In predicting extreme acute pancreatitis, the overall accuracy of the BISAP score is 82%. Conclusion: Current research shows that the scoring systems, i.e., all In the prediction of serious acute pancreatitis, APACHE II __ampersandsignamp; BISAP were comparable __ampersandsignamp; fine (SAP). The BISAP score was outperformed in precision, but with a good sensitivity __ampersandsignamp; negative predictive value compared to the APACHE II score.