Introduction: The sciatic vein serves as the most important collector of blood from the lower limb during the prenatal period. Sciatic veins are predominant veins of developing lower limb until 22 mm stage of the embryo, after which they involutes and the femoral system develops as a major venous system. Persistent sciatic vein (PSV) may be the failure of development of femoral vessels or failure in regression of sciatic vessels. Objective: To study the incidence of persistent sciatic vein on the lower limbs and review the literature on the subject. Methods: Fifty lower limbs from 25 cadavers preserved in formaldehyde were dissected at the department of Anatomy ANIIMS, during 2016 -2020, and the sciatic vein was observed in lower limbs. Results: The normal anatomy of the femoral veins were found in 48 among 50 limbs (96%). Persistent sciatic veins (PSV) were found in 2 of 50 limbs (4%). In one of the left lower limb, PSV was 54 cm long, originating from vena committees of the anterior tibial artery in the anterior compartment of the leg, having communications with the popliteal vein in the popliteal fossa. The PSV in one right lower limb was 37 cm long, originating from a popliteal vein near the apex of the popliteal fossa, running upwards in back of thigh accompanied by sciatic nerve. Conclusion: Sciatic vein (PSV) has been associated with patients with Klippel-Trenaunay Syndrome and in patients with recurrent varicose veins There is a high incidence of pulmonary embolism is seen in patients with PSV. Therefore, it must be investigated aiming at a better clinical or surgical management.