Introduction: Risk factors for coronary artery disease vary, but among them, factors that can be controlled by improving lifestyles include obesity, alcohol, smoking, lack of physical activity, stress, high blood pressure, diabetes, and hyperlipidemia. Objective: This study is a secondary data analysis study to identify the factors affecting working hours on health-related quality of life for people with coronary artery disease. The raw data is the National Health and Nutrition Survey (KNHANES) surveyed by the Korea Centers for Disease Control and Prevention from 2013 to 2017. Method: The subjects were 10,133 adults aged 19 or older who answered questions from doctors about whether to diagnose myocardial infarction or angina. EQ-5D was used as a tool for quality of life. The collected data were analyzed by using the SPSS WIN 25.0 program, using a stratified sample analysis method using stratification, colonization, and weighting. In the case of more than 40 hours per week and less than 50 hours, the subject__ampersandsignrsquo;s quality of life score was high (p__ampersandsignlt;.05). Results: The composite sample linear regression analysis, showed that males, the younger the age, the higher the quality of life, and the poorer the subjective health status, the lower the quality of life when the working hours per week exceed 60 hours. As a result of this study, to improve the quality of life of patients with coronary artery disease, it is necessary to develop a multidimensional nursing education program that includes physical, mental, and social aspects, including observing stable working hours.