Introduction: The ADR monitoring centre is under the PvPI working for the safety and welfare of patients, in coordinating all the clinical and respective paramedical departments by prompt detection, monitoring and reporting of the ADR and providing proper management. This study aims to evaluate the ADRs from our hospital so that physicians will be cautious while prescribing these drugs with ADRs. Objective: To study the adverse drug reaction in various departments of a tertiary care teaching hospital. Methods: A cross-sectional study conducted on 50 patients of all age groups who developed adverse drug reactions. Causality assessment was done based on Naranjo__ampersandsignrsquo;s probability scale. Modified Hartwig__ampersandsignrsquo;s criteria were used to assess the severity of ADRs into seven levels. Results: A total of 50 ADRs were reported, 44% were males and 56% were females. The female adult population was 42%. The majority of ADRs were due to antimicrobial agents, especially beta-lactam antibiotics (32%) followed by quinolones (10%). A maximum number of patients (74%)were reported with dermatological manifestations. The department of medicine reported the highest number of ADRs (20%). As per Naranjo__ampersandsignrsquo;s scale,56% of reports were assessed as possible. 54% of reports were documented as moderate according to Modified Hartwig__ampersandsignrsquo;s criteria for severity assessment. Conclusion: Hospital admissions due to adverse drug reactions (ADRs) are a major concern in the health care system. Healthcare practitioners need to be more conscious not only of the potential for adverse drug reactions but also of the avoidance (or) minimization of the incidence of ADRs.