IJCRRI Journ Cur Res ReInternational Journal of Current Research and ReviewI Journ Cur Res Re2231-21960975-5241Radiance Research Academy344Healthcare4__ampersandsign#39;-THIODNA: UNEXPECTED BEHAVIOUR ElzagheidMohamed I.110220163335This article is copyright of Popeye Publishing, 20092009This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.

This viewpoint briefly discusses the impact of 4__ampersandsignrsquo;-thiosubstitution on oligonucleotides behaviour. The study in the reviewed articles has shown unexpected A-form formation, and unexpected RNA-like behaviour of the 4__ampersandsignrsquo;-thioDNA. This has been confirmed by the unexpected interaction of 4__ampersandsignrsquo;-thioDNA with Lividomycin A, a RNA major groove binder, and by resistance to cleavage by DNase I, which is a DNA-specific endonuclease. 4__ampersandsignrsquo;-ThioDNAwas also recognized by RNase V1 which is a RNA-specific endonuclease. These all findings will trigger the main focus of this viewpoint.

Nucleic acids ThioDNAs 4’-ThioDNAs Structure and Properties