The progress of dentistry into an advanced science is a truly remarkable one. The importance and value of dental art and science as a humane service are well recognized. It was people of earlier periods who laid the foundations upon which current day dentistry has been built. The use of indigenous plants for the treatment of various health conditions has been documented since 6,000 BC throughout the Indian subcontinent. The popularity and widespread acceptance of this form of medicine stem from the easy accessibility to local herbs, lower cost, and the absence of any potential chemical additives which are present in conventional drugs. In dentistry, many of these have been studied for their cleansing action, antimicrobial, and antiplaque properties, due to their innate antioxidant and anti-inflammatory mechanisms. In this review, we intend to discuss the use of indigenous plants in treating various oral lesions. A literature review was conducted for finding a solution to show evidence on a metalevel. Two reviewers selected the articles to ensure the quality and reliability of the search protocol. Search engine like Google, Pubmed, Medline and Scopus were used with the key terms herbal extracts, alternative medicine, oral lesions, phytotherapy. Medicinal herbs have been found to possess anti-inflammatory properties and some even demonstrated to have anti-cancer properties. In developing countries still, herbal medicine is considered to be the main system in treating many diseases since it is affordable. But, the end-users should be given sufficient scientific evidence to use them which can be achieved by conducting scientific experiments to confirm their safety and efficacy.