Introduction: Transscleral cyclo-photocoagulation (TSCPC) is a cyclo-destructive procedure which targets the secretory epithelium of the ciliary epithelium and applicable to reduce intraocular pressure. Objective: To compare the outcomes of transscleral diode cyclo-photocoagulation using short-duration (SD) versus long-duration (LD) burn treatment in ASEAN brown iris patients. Methods: We analysed retrospective data from twenty-five eyes with glaucoma cases of any type who underwent cyclo-photocoagulation with SD (2000 ms) with variable power of __ampersandsignle;2000 mW versus LD (4000 ms) treatment with variable power __ampersandsignle;1200mW. The intraocular pressure (IOP) and the number of antiglaucoma eyedrops reduction, visual acuity changes, and complications between the two techniques were documented. Results: The mean IOP before treatment was 47.2 (8.4) mmHg and 30.15 (7.7) mmHg for SD and LD group respectively. At the final visit post-treatment, there was a reduction of IOP in both groups having 28.0 mmHg in SD (p__ampersandsigngt;0.05) and 22.15 mmHg in the LD (p0.05) and 1.8 for the LD group (p__ampersandsigngt;0.05). The mean logMAR visual acuity before treatment was 2.46 (SD) and 2.10 (LD) and at the post-treatment, the mean logMAR was 2.70 (SD) and 2.10 (LD) (p__ampersandsigngt;0.05). Both treatments resulted in complications such as inflammation, hypotony and hyphaema. Conclusion: Both treatments reduced the intraocular pressure, and the number of antiglaucoma eye drops needed in ASEAN brown iris glaucoma patient. Comparatively, complications such as inflammation, hypotony and hyphaema were more in the LD group.