Introduction: Kidney stone disease should be viewed as a systemic disorder, associated with hypertension, insulin resistance, chronic kidney disease and cardiovascular damage. Mutrashmari (Renal calculi/ Kidney stones) is one among the Ashtamahagada (eight fatal conditions) and is Kaphapradhan Tridoshaja Vyadhi. It is correlated with urolithiasis. The prevalence of symptomatic urolithiasis is approximately 10 per cent in men and 5 per cent in women. Many treatment modalities have been introduced in medical sciences, but it is very costly and even the recurrence of production of stone cannot be prevented. Objectives: To find out easily available, a cost-effective medicine to treat Mutrashmari. The available treatments options for prevention of stone recurrence can be divided into lifestyle interventions and pharmaceutical therapies. Case Presentation: In the first follow-up; the patient informed the stone was expelled out through urine, and he experienced moderate pain and disturbance in the urine flow on 30th day. The patient got moderate relief from pain in the abdomen and did not experience dysuria. Conclusion: Our present findings suggest that Chandraprabha Vati, Ayurvedic Formulation Tablet, Varunadi Kshaya is a safe and effective approach for the management of patients with renal stones.