Background: Methicillin-resistant S. aureus (MRSA), a major nosocomial pathogen is a challenge in treatment as it is ineffective to most antibiotics. So quick and accurate detection of MRSA is essential to avoid treatment failure and to contain the spread of this organism. Objective: This study aims to compare the conventional cefoxitin disc diffusion method with MRSA Chrom agar method for detection of MRSA and to note the resistance pattern of the organisms. Methods: In this prospective study S.aureus identified using conventional methods for the pus, nasal swabs and blood samples as a part of surveillance by hospital infection control unit. All S.aureus were screened for methicillin resistance by cefoxitin disk diffusion, MIC (by Vitek 2) and MRSA Chromagar.S.aureus ATCC strains were used for quality control. Antibiotic sensitivity was done by Kirby Bauer__ampersandsignrsquo;s disc diffusion method using CLSI guidelines. Data maintained in Microsoft office Excel was analyzed with statistical tools such as the Chi Square test for significance. Results: Out of 125 S. aureus isolated, 48 (38.4%) were MRSA. By cefoxitin disk diffusion method the sensitivity and specificity were 100% and 100% respectively when compared with Vitek2 MIC while, the sensitivity and specificity of Chromagar-MRSA were93.75% and 97.36%, respectively. The earliest turnaround time for MRSA identification with the conventional method was 48 hours (37.5%) only while by Chrom agar detection 91.11% were identified in the first 24 hours itself. All MRSA isolated were susceptible to Vancomycin, Linezolid and resistant to commonly used antibiotics. Conclusions: Cefoxitin disk diffusion method is having higher sensitivity and specificity for MRSA detection than the Chrom agar MRSA method. As the later is having good sensitivity, specificity and can detect the majority of MRSA with a significantly less TAT, it can be used for screening of MRSA.