Introduction: The Importance of quadrant location on the prognosis of breast lesions has been investigated for many years. The results are variable. Objective: To determine the prevalence of breast lesions in various quadrants and to assess the nature of breast lumps based on their cytomorphological reports. To determine the prognosis based on their location. Methods: Clinical history, radiological imaging, and physical examination were done noting quadrant of location along with the bilateral examination of nipple, axilla __ampersandsignamp; lymph nodes. FNAC was done with a 22-gauge needle. Cytomorphology evaluation carried out on Hematoxylin and Eosin and Giemsa stained smears. Results: Out of the total n=73 cases n=29 Fibroadenoma cases 58.62% cases were in the Lateral upper Quadrant and 13.79% cases in the Medial Upper Quadrant and 10.34% were found in the Lateral Lower Quadrant and Central area 6.89% cases were detected. In the malignant cases, Invasive duct cell carcinoma (IDCC) was diagnosed in n=10 cases out of which 70% cases were in the Lateral upper quadrant and 30% cases in Medial Upper Quadrant. Conclusion: Among the benign lesions fibroadenoma showed the highest occurrence whereas in malignant lesions, it was IDCC and the Lateral outer quadrant showed the highest involvement for fibroadenoma among the benign lesions and IDCC among the malignant lesions. Therefore, it can be concluded that lesions occurring in the lateral upper quadrant may carry a good prognosis.