Environmental factors can impose most of their harmful effects, including harmful substances and drugs, by modifying the usual sequence of genes, advances to unusual expression or attempting to silence the major DNA sequences and their encoded proteins. Epigenetic is the research of modifications of DNA sequences and subsequent proteins, with no modification of the nucleotide sequences, Methylation of the DNA, alteration in Histone and RNA-mediated targeting control. Many biochemical reactions influences in human cell function, a pattern of their modification occurs in alcoholics. This review is focused on the regulation of gene expression by the epigenetic mechanism in alcoholics. Chronic consumption of alcohol in humans affects the brain, bringing the modifications in the expression of genes. Chronic alcohol intake also creates the desire for alcohol, loss of control, ultimately leading to liver damage. Such changes result in the expression of gene and cell cycle disturbance, facilitating the development of cirrhosis and cancer of the liver. DNA methylation, histone modifications and miRNA are the important common epigenetic modifications used as biomarkers of alcoholic liver disorders. While we are in the early stages of understanding the complex epigenetic regulatory system, the preliminary evidence provided here indicates that we could be at the dawn of the advancement of epigenetic factors in the diagnosis of various disorders.