Objective: The work aimed at making mini-tablets filled capsules for the prevention of post bypass surgery heart stroke using Atorvastatin (ATN), and Acetyl Salicylic Acid (ASA). Methods: The mini-tablets (MTs) of ATN were uncoated, and ASA was enteric-coated. A novel approach was adopted in tackling gastric irritation of ASA, by using Plantago ovata seed mucilage as a binder in making the MTs. MTs of ATN and ASA were placed in capsules. ATN and ASA compatibility with excipients used were checked by DSC and FTIR studies. All prepared MTs were prosecuted for post-compression constraints. Results: The prepared MTs confirmed no interaction by FTIR and DSC studies. All the MTs passed the physicochemical constraints. ATN was released within 60 min, whereas enteric-coated ASA, showed its resistance to release in an acidic environment (2h) and favour in an alkaline buffer (within 45 min). Conclusion: The study concludes that by using P. ovata as a binder in making tablets will resolve the issues related to gastric irritation.