Ayurveda Immune boosters (AIB) are Rasayana drugs which increase the number of white blood cells and train them to fight against microbes causing diseases. Some of them kill microorganisms, increase immunoglobulin, repair of DNA of an inflamed cell, increase Agni, and conditioning the gut to increase the beneficial gut microbiota. This review aimed to generate scientific evidence for Ayurveda Immune boosters (AIB) are effective to prevent and cure COVID-19 infection or it is a myth through Ayurveda and modern literature review. The properties of Rasayan are reviewed from Ayurveda Literature. The immunopharmacology, mechanism of immuno-booster and Rasayana herbs are reviewed from current medical literature for its subclinical and clinical evidence. Ayush kwatha and single herb like Guduchi (500-1000mg) extract, Aswagandha powder (3-5gm), and Haridra milk/gargling recommended as AIB by the Ministry AYUSH are safe and effective for prevention and cure of COVID-19 with sufficient preclinical and some Randomised clinical trials (RCT) evidence. So, the myth of Traditional Ayurveda herbs won__ampersandsignrsquo;t boost our immunity to the virus is not true rather Ayurveda Medication (AIB) can boost our immunity to fight against COVID-19. More RCT evidence is required for clinical practice.