A systematic review was conducted using PRISMA guidelines. Studies, case series, clinical trials mentioning the treatment of leukoplakia with herbal modalities were included. Data are available on follow-ups of herbal treatment modalities for leukoplakia. 7 out of 10 studies were picked up for inclusion and were included in the systematic review. The effectiveness of various herbal treatment modalities for the management of leukoplakia was reviewed. With the help of abstracts and titles, the preliminary screening of the recovered studies was done. In studies whose results were found to be unclear, its corresponding full text was read. The studies where independently evaluated by authors and the results were discussed until a decision was made by a general agreement. 7 out of 10 studies were picked up for inclusion and were included in the systematic review. Several treatments exist for treating this __ampersandsignldquo;potentially malignant lesions__ampersandsignrdquo; even including some surgical, as well as non-surgical treatment plans but the spectrum of herbal medicine surely, brings a new ray of hope. The most meritorious effect of herbal medicine is that it interacts with the specific chemical receptors within the body and has less side effect as compared to traditional medicines. Herbs are very good anti-oxidants, anti-bacterial agents, anti-inflammatory agents as well as good sedatives and anxiolytics hence play a very useful role in the treatment of oral diseases.