Introduction: Many methods have been recommended for the prevention of hemodynamic instability during induction of anaesthesia. Objectives: To study Midazolam plus Fentanyl versus Midazolam plus Propofol concerning Hemodynamic stability during regional Anaesthesia. Methods: We have conducted a comparative study of conscious sedation using midazolam with fentanyl in group-I Vs. midazolam with propofol in group-II. This study was conducted at a tertiary care centre for one year. 120 patients of ASA Grade I, II and III, were randomly divided into two groups, 60 in each group, of between 15 to 60 years. Results: Systolic blood pressure changes in both the groups are comparable with each other at 30 minutes after sedation but fall in blood pressure was more in group II from the baseline. Statistically p__ampersandsignlt;0.001 is highly significant in both groups. Conclusion: It can be concluded from our study that Systolic blood pressure changes in both the groups are comparable with each other at 30 minutes after sedation, but blood pressure fall was more in Midazolam plus Propofol group from the baseline.