Introduction: Oral cancer is the eighth most common cancer and accounts for 2% of cancer death worldwide. In India, Oral cancer accounts for 30-50% of all cancers; with squamous cell carcinoma the most common. Radiologic assessment of bone invasion plays a major role to evaluate the extent of surgical bone resection. Objective: This study compares osseous changes in OSCC using Orthopantomogram (OPG) and Cone Beam Computed Tomography (CBCT). Methods: A retrospective analysis of patients who visited the Department of Radiology from June 2019 to March 2020 was included in the study. After reviewing 67 case records, 12 patients who were clinically and histopathologically proven as OSCC patients, and had undergone imaging, both OPG and CBCT for assessment were selected. Results: The study subjects included 4 female (33.3%) patients and 8 male (66.6%) patients. The predominant age group in the study was 40-50 years (41.7%). OSCC frequently involved mandible (75%); the posterior region (91.7%) and the commonly reported TNM staging were stage IV-A (66.6%) followed by stage-III (33.3%). Comparison of the OSCC and internal structure appearance in OPG there was a positive correlation seen and in comparison, to CBCT it was not statistically significant. On comparison for the involvement of adjacent structures and OSCC in OPG and CBCT, there was no significant difference noticed. Conclusion: CBCT can be recommended for imaging oral carcinoma of the maxillofacial region replacing 2D and high exposure medical CT imaging.