Introduction: Hypertension is one of the factors associated with stroke, congestive heart failure, heart or kidney failure. Overweight and obesity are the two most key determinants of health that leads to adverse metabolic changes including increase in blood pressure. The cellular components of blood contribute to the viscosity and volume of blood, thus playing a vital role in regulating blood pressure. Objectives: To compare the hematological parameters and anthropometric indicators in hypertensive and normotensive males. Materials and Methods: This was a hospital based case control study which included 60 normal healthy male subjects and 60 hypertensive male subjects. Blood pressure was measured in supine position by mercury sphygmomanometer. Hematological indices were estimated using an autoanlayser. The data collected were entered and analyzed using software Statistical Package for the Social Science 16.0 (SPSS 16.0). Results and Discussion: The mean levels of hemoglobin and hematocrit were significantly lower in the hypertensive group compared to the normotensives in our study. The anthropometric measurement waist hip ratio, showed a statistically significant positive correlation with systolic blood pressure. Multiple regression analysis showed waist hip ratio, hemoglobin and hematocrit were significant predictors of systolic blood pressure. Conclusion: The present study concludes that Waist hip ratio, a simple and inexpensive anthropometric measurement can be used as a significant predictor of systolic blood pressure. Also monitoring of hematological indices like hemoglobin and hematocrit is essential in the prevention of development of cardiovascular complications in hypertension.