Background: Patients undergoing head and neck oncological surgery are at great risk of developing complications especially postoperativeworld infection. Objective: The purpose of the study was to analyze the type of prophylactic administration of antibiotics. Methods: All the surgical and medical records of the patient from June 2019 to March 2020 was collected. Some patients had bacteriology data from wound swabs of patients were collected from the department of oncology and department oral and maxillofacial surgery. Results: Total of 39 patients out of which 11 patients had single antibiotics and 28 patients had a combination of antibiotics given. It was found in our study that most of the patients were administered with cefixime and metronidazole. Patients undergoing head and neck oncology surgery are at great risk of developing complications especially post-operative wound infection. Antibiotherapy seems to have efficacy when administered prophylactic in head and neck surgical procedure. Conclusion: To conclude our study, although we have other antibiotics used in head and neck cancer operated patients but Cefixime and Metronidazole, Ciproflaxicin were relatively more and commonly administered to patients affected with head and neck carcinoma.