Background: Cancers of all regions of the oral cavity, taking into account worldwide reports is considered to be represented as the sixth most common cancer in the world. Oral cancers are believed to result due to the accumulation of genetic and epigenetic alterations. Over the past few years, there has been an increasing trend in prevalence among younger persons. This makes Oral cancer a highly relevant issue of global public health. Objective: The aim of the present study is to evaluate the prevalence and age distribution of Oral Squamous cell carcinoma (OSCC) in patients of an institution. Methods: The study is a hospital-based retrospective study, and included patients visiting a Dental hospital. A total of 45 patients diagnosed with OSCC were included in the study. The age, gender, anatomic site, and history of habit were evaluated and tabulated in MS Excel. The data collected was imported to IBM SPSS Version 20.0 for Chi-Square analysis and results were obtained. Results: It was observed that OSCC was most prevalent in patients around 56 years of age. The lower arch was found to be the most frequent site of presentation (47%). The association between gender and the occurrence of OSCC was not statistically significant (p__ampersandsigngt;0.05). Conclusion: Within the limits of this study OSCC was found to be most prevalent in the 5th-6th decade of life in the lower arch