Introduction: Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral cavity, associated with poor prognosis. Risk factors associated are tobacco, alcohol, pan chewing, nutritional deficiency, etc. Metastasis is more commonly to cervical lymph nodes various studies have been done to study the pattern of metastasis, which helps surgeons predict the pattern and treatment planning. Objective: To evaluate the correlation between the site of occurrence of lesion and Levels of lymph node involvement in (OSCC) patients. Methods: This is a retrospective study conducted in an institution, a totally of 34 patients who were diagnosed with oral squamous cell carcinoma were included. Demographic data was collected from the management software and tabulated in a Microsoft Excel sheet and used for statistical analysis. Association between the site of lesion and Level of lymph node involvement is studied using the Chi-square test. Results: Well-differentiated squamous cell carcinoma (WDSCC) was more common than moderately differentiated squamous cell carcinoma (MDSCC). The more common site of lesion with lymph node involvement is tongue and buccal mucosa than the retromolar region and gingivobuccal sulcus, 60% of lesions in buccal mucosa show involvement in Level-1B and 2 followed by the tongue (45.5%) more in Level-5. The correlation between the site of lesion and Level of nodal involvement did not show statistical significance. Conclusion: This study provides a predictive model that appears to be reliable, simple, and may help as a guide for surgeons in planning neck dissections before surgery.