Aim: The aim of the study is to explore the influence of stress in patients with temporomandibular disorders Objectives: Stress affects the physiological, cognitive, emotional, behavioural functioning of human being. Initially our body compensates for stress, but when we cannot cope up with it, disorder arises. One such manifestation of stress in human body is temporomandibular disorders. The objective of the study is to first establish the diagnosis of the patients__ampersandsignrsquo; complaints pertaining to temporomandibular joint based on clinical and radiological examinations; then to assess the degree of stress using stress assessment questionnaire and finally to study the relationship between stress and adaptability in temporomandibular disorders. Materials and Methods: 60 patients who reported with pain, tenderness in the temporomandibular joint, clicking or crepitus, tenderness in muscles of mastication, restricted mouth opening, deviation of jaw, restricted jaw movements, and with altered condylar movements were selected for the study. Clinical examination of signs and symptoms were assessed along with a stress assessment questionnaire. Finally, statistical analysis was performed on the responses received from the patients. Results: Significant difference was found in the pain threshold i.e. pain perception between patients with stress and without stress. This leads to the conclusion that stress has a major role in affecting the adaptability of the body, and it is a front runner for various deleterious effects. Conclusion: Stress levels of patients with temporomandibular disorders should be always evaluated and in case the stress levels are high, it must be treated with appropriate stress management therapy.