Background: Worldwide Oral Squamous Cell Carcinoma (OSCC) is one of the most frequent malignancies, and it carries a bad prognosis with a global mortality rate of 1.9 deaths per 100,000 per year. Most cases of OSCC are preceded by asymptomatic clinical lesions collectively referred to as Oral Potentially Malignant Disorders (OPMDs). Objectives: The objective of the study was to describe the prevalence of Non-habit-associated OSCC and site predilection among patients visiting our institution. Methods: Of 50 oral squamous cell carcinoma, 15 cases were treated between July 2019 to February 2020 in our institution were identified as not having the habit of tobacco use during their lifetime. These cases were reviewed to gather data on multiple clinical-pathological variables. Results: The mean age of non-habit associated OSCC of the oral cavity was 59.9 years and 60% were males. The tumour was more commonly seen on the tongue followed by buccal mucosa. Conclusion: The Non-habit-associated OSCC is seen more commonly in the elderly with a male predilection.