Background: Injuries from burn remain the second largest group of injuries after road traffic accidents. Approximately 1-1. 5 lakh people die from burns and around 2.8lakh people require multiple surgeries and prolonged rehabilitation. Objectives: To evaluate independent prognostic factors of burns injury and evaluation of RPR as an important risk factor. Methods: The present retrospective study patients of all age groups admitted to burns department from 1st March 2018 to 31st May 2018 with variable %TBSA burned were included. For 100 patients noted the clinical details like age, gender, burn index, inhalation injury if present, complete blood count, blood urea and serum creatinine levels. Medical notes were used to retrospectively record the patients. Their blood samples were routinely collected between 5 am and 7 am during 5th, 7th, 10th and 20th-day post-burn. The medical records were used to document the time from injury to adverse events. Results: The age, % of burns, RDW, RPR, MPV, WBC, urea and creatinine values were considerably high in patients with mortality in the day 5, day 7, day 10 and day 20 datasets, whereas the haemoglobin, platelet values were low. Conclusion: In this study, results indicated that parameters like haemoglobin, RDW, blood urea and serum creatinine and % of burns are statistically significant independent mortality predictors in burn patients. Whereas, RPR did not prove to be a statistically significant independent mortality predictor.