Introduction: In India, around 2.0__ampersandsignndash;2.5 million people are living with one or another kind of cancer menace and above 7__ampersandsignndash;8 lakhs new cases added every year to the existing burden. Availability of data in this regard is mostly from developed countries where the social-demographic scenarios are quite different from developing countries on comparing data from developed countries. Although fewer studies had been carried out in India in this regard seems to be non-sufficient for addressing the problem. Objective: To explore social-demographic predictors of Caregiver burden among caregivers of cancer patients attending cancer hospital Jabalpur. Methods: This is a descriptive cross-sectional, hospital-based study conducted in cancer hospital Jabalpur in 340 caregivers. Chi-square test was applied to determine the association of study variables with caregiver burden. Results: Mean scores as assessed by ZBI was found to be 38__ampersandsignplusmn; 11 (median = 36). 197 (57.9 %) caregivers were male, 143 (42.1%) were female. 81 % of males feel cared for giving burden, while among females only 55 (41.4%) feel it. Despite contributing only 40.6% study population, urban caregivers experienced significantly high (82%) caregiver burden. the maximum caregiving burden observed in middle class 86.4%, which constitutes only 25% of the study population and the caregiver burden was found statistically significant. Conclusion: These finding suggested coping with the problem of care-giving burden more policies and programmes in this direction should have been planned with special attention particularly to reduce burden amongst those having more suffering.