Introduction: The course of purulent wounds against the background of diabetes and the accompanying thyrotoxicosis is one of the urgent tasks of modern purulent surgery Objective: Improving the results of treatment of purulent wounds in patients with a combined pathology of thyrotoxicosis with diabetes mellitus, by studying disorders of protein metabolism. Methods: A retrospective analysis of the clinical course of purulent surgical diseases associated with thyrotoxicosis in patients with diabetes mellitus (DM) and an assessment of protein metabolism disorders in this category of patients was performed. Thyrotoxicosis in combination with diabetes was diagnosed in 104 (16.8%) of 619 patients treated in the clinical base of BSMI Results: In patients with purulent surgical diseases associated with thyrotoxicosis on the background of diabetes, there is a pronounced violation of protein metabolism, which negatively affects the course of the wound process. Conclusion: Timely correction of hormonal disorders in thyrotoxicosis and hyperglycemia leads to better treatment results. Such patients must be treated by an endocrinologist.