Introduction: The imbalance between proinflammatory cytokines impairs the permeability in blood vessels resulting in increased blood pressure. In preeclampsia, patients found an increase in IL-6 levels compared to normotensive mothers. Objective: To determine differences in levels of cytokines IL-6 in pregnant women with preeclampsia and normotension in the Bugis, Makassar, Mandar and Toraja tribes so that it can be used as a marker for the prevention of the continuation of advanced preeclampsia and is used as one of the determinants of early detection. Methods: This research is a cross-sectional study with a case-control study where respondents were 44 pregnant women with a gestational age over 20 weeks with a diagnosis of preeclampsia and 44 pregnant women over 20 weeks with normotension. The criteria for respondents in this study were not suffering from systemic diseases and were domiciled in the study area which was the Makassar, Bugis, Mandar, and Toraja tribes. Data collected included age, body mass index (BMI), parity, history of preeclampsia, and Tribal Status. Serum Interleukin levels were determined using the Human Interleukin 6 ELISA Kit. Results: Differences in mean IL-6 levels in the preeclampsia group in four ethnic groups namely Makassar, Bugis, Mandar and Toraja with a significant value of p-value 0.032 (p__ampersandsignlt;0.05) as well as in the normotension group also had differences in IL-6 levels with a p-value of 0.002 (p__ampersandsignlt;0.05). While the difference in IL-6 levels of preeclampsia and normotension in each tribe results in significant differences in Makassar (0.001) and Toraja (0.010). Conclusion: Differences in serum IL-6 levels in Makassar, Bugis, Mandar, and Toraja ethnic variations must be considered risk factors that influence the incidence of preeclampsia.