Introduction: In recent years the use of the minimally invasive technique of treatment is giving quite promising results not only in cosmetics but also in dentistry. Botulinum toxin is injected in the affected muscles which in turns inhibits the acetylcholine and results in the reduction of the tone of muscles. The commonly used name for Botulinum toxin is BOTOX. There are seven serotypes of botulinum toxin. Mainly two types are used. Patients who are contraindicated for conventional therapies can easily undergo BOTOX therapy as it is a preventive treatment at low cost. Aim and Objective: This review article explains about the various applications of botulinum toxin for painful conditions in dentistry and also for aesthetics.