Introduction: Dhatura (Dhatura metel) is cerebrotoxic, Deleriant poison which is also classified as Upavisha in Ayurveda. Various poisons have been described in Ayurveda along with their antidotes. Mode of action of these antidotes is not mentioned in texts. In Ayurvedic literature According to Basavrajeeyam under the heading of Vish-Prativishani, Chincha Rasa and Kamal Patra churna have been described to be possessing antidote action which may act by some way to counter toxicity of Dhatura. It is necessary to verify the efficacy of these antidotes on scientific parameters so that it can be useful in emergencies. Objectives: To establish the action and mechanism of Kamal Patra Churna against toxic effects of Dhatura on albino mice. Methods: Swiss albino mice were selected as an animal model and antidote potential of kamal patra against datura poweder is evaluated by measuring body temperature, time of convultions and survival rate. Results: Kamal patra administration before datutal poisoning reduced the toxic effects of datura such as hypothermia, convulsion and increased the survival rates. Conclusion: From this study, we can conclude that Kamal Patra can resist the toxic effects of Dhatura up to some extent.