Introduction: Various clinical factors related to the life quality of schizophrenic patients have been reported. Objective: This research aims to evaluate the cost and utility of the use of risperidone or haloperidol combinations on schizophrenic patients in the cases at Prof. V. L. Ratumbuysang Psychiatric Hospital North Sulawesi Province of Indonesia. Methods: This is an observational study with a Cohort design. Sampling was done using a purposive sampling method for all 82 patients and finally obtained 22 patients for the risperidone-combination group and 28 patients for the haloperidol-combination group. Data were collected from patient__ampersandsignrsquo;s medical records by using retrospective approaches from April to July 2018 and prospectively by using a short-form questionnaire. The utility based on the quality of life was assessed by the 36-item Short Form (SF-36) questionnaire. The quality-adjusted life years (QALY__ampersandsignrsquo;s) for haloperidol-combination were recorded as 0.433 which more high than the risperidone-combination group, which recorded as 0.423 Average cost-effectiveness ratio (ACER) for the risperidone-combination group was IDR 5.813.716,13/QALY__ampersandsignrsquo;s, which more cost-effectively than the haloperidol-combination group of IDR 6.454.822,17/QALY__ampersandsignrsquo;s with the record of incremental cost-effective ratio (ICER) of IDR 33.573.600/QALY. Results: The result of sensitivity test to 25% total cost increase for the risperidone-combination group (IDR 7.267.145) and the 25% total cost decrease for the haloperidol-combination group has changed in ACER values with compared to the baseline of the risperidone-combination group. Conclusion: Risperidone-combination is the dominant therapeutic choice related to cost and QALY__ampersandsignrsquo;s in the treatment for schizophrenic patients.