Background: Obesity leads musculoskeletal problem which is affecting the Spinal disorder are related to low back pain. This is more affected in obese people with the impact of workload. The Sciatica is a clinical condition characterized by severe pain started from the low back region and radiating down along the course of the leg. Very few studies were conducted in the Indian population. Therefore, an attempt has made to study the NCV in obese patients of sciatica pain common. To the observer the relation of overweight and obesity with sciatica pain. Methods: The study was carried in the physiology department in which we have included 100 patients, which was suffering sciatica. The patients were evaluated for the straight leg raising test (SLR) positive. These patients were referred to the NCV based on BMI for rule out the obesity. NCV study was done on RMS EMG EP Mark-II. Result: The mean value of Motor nerve conduction velocity was 51.79+3.46 in a normal subject and it was 48.02 + 5.17 on the in an obese subject which was significantly decreased. Conclusion: We conclude that obese patients are increases risk of radiating pain which is specific in men and women. Taking into consideration the recent situation of worldwide obesity we emphasis on the does obesity lead to sciatic pain. We found sciatic neuropathy in obese patients.