Objective: This study was aimed to determine the prevalence of PMS, the relationship of nutritional intake, mental status, and levels of 8-OHdG in urine with PMS events and to find a predictor model of PMS events. Methods: Observational analytic study design case-control study and cross-sectional study (hybrid method), samples of 90 students class X and XI at SMAN 21 Makassar was conducted in February-March 2020. Data included 2x24 hour food recall, food frequency questionnaire, stress, depression and anxiety scores, and 8-OHdG levels in girls__ampersandsignrsquo; urine. Data analysis using chisquare test, receiver operating characteristic curve analysis, and logistic regression. Results: The prevalence of PMS was 28.9%. There was a significant correlation between fat intake, calcium, zinc, stress, depression, and urine 8-OHdG levels with the incidence of PMS (p__ampersandsignlt;0.05 and p__ampersandsignlt;0.01). Stress and 8-OHdG levels in urine as a predictor of PMS events (p__ampersandsignlt;0.01; R2 = 0.208). Conclusion: Stress and 8-OHdG levels in urine can be a predictor of PMS events.