Background: Rasashastra and Bhaishjya Kalpana, the pharmaceutical and therapeutic branch of Ayurveda consists of various varieties of dosage forms of medicine and Kshara Kalpana is one of the medicaments among them. Kshara is an alkaline substance prepared from the ashes of plants, animals or minerals. In compendia, Palash (Butea monosperma Lam)is referred to as __ampersandsignldquo;Kshara- Shretha__ampersandsignrdquo;. Objectives: To standardize the method of preparation of Palasha Kshara by preparing it with two combinations i.e. one with Palasha Panchanga and the another is with roots, stem, and leaves of Palasha Plant and to evaluate their diuretic action in Wister rats. Methods: The procurement and authentication of parts of Palasha plant will be done according to the Dravya Guna Department, MGACH __ampersandsignamp; RC, Wardha. Both combinations of Palasha Kshara will be prepared by using the reference of the text Rasa Tarangini. Expected Results: The pharmaceutical- analytical study may reveal that which combination has more efficacies for the diuretic action. The data will be assessed for its pharmaceutical, analytical and experimental results by using Unpaired __ampersandsignlsquo;t__ampersandsignrsquo; test and One way ANOVA test. Conclusion: The method of preparation explained in compendia i.e. using Palasha Panchanga has same analytical results and diuretic action as that of the altered one i.e. using the parts of Palasha plants which are available all the year along. Key Words: Palasha Kshara, Ayurveda, Alkali Preparation, Two combinations, Diuretic action, Pharmaceutics, Analytics, Standardization, Experimental Study