Background: Wet fixed smears are commonly used for routine investigation in determining many precancerous and cancerous lesions. Wet fixed smears are associated with few side effects which leads to diagnostic difficulties. Therefore the present study is used to determine the effects of rehydration on air-dried smears by comparing cellular preservation and staining quality in rehydration smears and wet fixed smears. Objectives: 1) To compare the cytomorphological features in conventional Pap smears and rehydration air-dried Pap smear. 2) To compare the staining quality in rehydration smears and wet fixed smears. 3) To identify if rehydration techniques can be used as an alternative method particularly in rural setup or in resource-limited settings. Methods: Our study is a prospective analytical study to be conducted in Cytopathology section of the Department of Pathology. 100 fluid sample were examined during the study period. Wet fixed smears are processed routinely. Air-dried smears are rehydrated with normal saline for thirty seconds and immediately added to the jar containing fixative 95% ethanol for thirty minutes. Both the smears were then processed and stained by the Papanicolaou technique. Both the smears will be screened, assessed and graded for various cytomorphological parameters. The cervical smears will be reported as per the 2014 Bethesda system. Expected Results: Statistically significant similarities can be observed in between two groups one with wet fixed smears and other with rehydrated air-dried smears when compared for various cellular features. On comparing two groups for its cytological diagnosis, results can be found out in the agreement. The rehydrated air-dried technique can be used effectively for FNACs, Effusion fluids, Exfoliated cells. Interpretation of rehydrated air-dried smears and staining quality is far better when compared to conventional wet smears. Conclusion: The conclusion will be based on the results of the study