Background: Ayurveda believes Raktamokshan to be an idiosyncratic minor operative procedure useful in treatment for letting blood in conditions where blood is vitiatedancient sages of Ayurved like Acharya Sushruta, who is considered as the father of ancient Indian surgery narrates about normal and disturbed functioning bit part of Rudhira and its major role in various operative methods. More than a bloodletting therapy, an amazing cocktail of medicinal substances is present in the salivary secretions of the leech. This has led to its therapeutic utilization in countless medical and surgical ambiences. About the environment and normal body conditions, parameters related to blood are essential. The foreign bodies present in blood can be disclosed from the evaluation of haematological and differential parameters. The estimation of this criterion: Erythrocytes, leukocytes and thrombocytes give the approach to evaluate the presence of assorted module in the blood of animals which is been instrumental in pathological, physiological, and nutritional status of animals. Objectives: To Evaluate of Haematological Parameters of Leech Application in Acute Inflammation by assessing the changes in the haematological parameters (CBC with ESR) before and after 24 hrs of leech application in acute inflammation. Methodology: 20 Patients of age group between 20 to 50 years of either sex with acute inflammation indicated for leech therapy will be selected, Nirvisha leech used for medicinal purpose Hirudo medicinalis will be applied and haematological changes will be compared before and after leech application. Results: After data analysis results will be noted. Conclusion: Few changes will be seen in haematological parameters.