Background: The impact of the environment on Male Infertility has shown the effect on, mood disorders, cancers at the genital region, declination in sperm concentration and multiple alterations in sexual behaviour. In the case of male infertility in the Indian population, some studies have also concluded that a specific mutation on MTHFR (Methylen etetrahydrofolate_Reductase) at C677T site is quite briefly associated with the male infertility problem. Similarly, in males; increased susceptibility to various complex disorders have been reported for the same type of mutation. Objectives: To correlate MTHFR gene polymorphism and occupational environmental factors with defects in morphology, count and motility of sperm by normal sperm. Methodology: Details of the occupational environment of the individual patient before Semen analysis. The semen analysis will be performed according to the WHO Guidelines 2010. Blood samples will be collected from patients matching the inclusion criteria, then Cryopreserving of sediments of blood samples will be done if required. Extraction of genomic DNA from blood Genotyping of MTFR gene PCR-RFLP method Identification of genotype by Electrophoresis and then Statistical analysis will be done for checking occ. Environmental factor effect with MTHFR gene polymorphism Comparison of epigenome between defected sperm and healthy sperm. Expected Results: Three variable groups (Heat; Telecommunication radiation and chemical) will be formed concerning the exposure of environmental occupation on fertility perspective. Eventually, the severity of epigenetic cause for male infertility is expected to see in participants with __ampersandsignplusmn;15 years the exposure of any one or a combination of the variables of occupational environment.