Background: Tamakashwasa (bronchial asthma) is a disease of Pranavaha Srotasa (Respiratory system) in which Kapha and Vata Doshas are having supremacy. It is a chronic inflammatory airway disease characterized by dyspnoea, cough, expectoration, wheezing, coryza, dyspnoea, hoarseness of voice. It affects the quality of life and takes economical implication over the patient as well as society. Vamana (therapeutic emesis) is an internal purificatory practice which is the best among all the Panchakarmas for the elimination of morbid Kapha Dosha. It is mainly indicated in Tamakshwasa having Bahudoshavastha. Objectives: To study the effect and safety of Jeemutaka and Ikshwaku Vamana and to compare with Madanaphala Vamana in Tamakshwasa. Methods: In the present comparative clinical trial, 90 patients of Tamakshwasa will be divided into 3 groups (30 patients in each group). Group A: Madanaphaala Vamana, will compare with Group B: Jeemutaka Vamana and Group C: Ikshwaku Vamana in Tamakshwasa. Patients with symptoms of Tamakshwasa will be assigned randomly into three groups and Vamana will be given after 1 day Snehapana and on the second day, Vamana will be performed after Bahyasnehana and Swedana at 7 a.m. Samsarjana Krama will be given for 3 days and assessment will be recorded on 0th, 5th day. Expected Results: The Result will be evaluated based on subjective and objective parameters. Conclusion: Madanpahala, Jeemutaka and Ikshwaku Vamana will be effective and safe in Tamakshwasa to the improvement of Peak expiratory flow rate (PEFR).