Introduction: Perimenopause is the time between the onset of waning ovarian function associated with menstrual irregularity and vasomotor symptoms and the year after the last menses. This period is characterized by irregularities of menses; lengthy and heavy menses with episodes of amenorrhea, sub-fertility, hot flushes which falls under vasomotor symptoms, a psychological symptom like insomnia. Objectives: To evaluate the effect of Ashwagandhadi ksheerbasti on psychological symptoms, vasomotor symptoms and serum estradiol fluctuations in perimenopause with the administration of Ashwagandhadi kheer Basti along with counselling in one group and only with counselling in other groups. Methods: In age group ranging of 41-50 years, women suffering from perimenopausal psychological and vasomotor symptoms meeting the criteria mentioned in standard score scale included in the study. Expected Results: Recent studies show bone marrow transplantation restores follicular maturation and steroid production in mouse models for primary ovarian failure. Follicular recruitment occurs in the bone marrow before ovaries. We postulate a theory based on Ayurveda principle stating, the base of the reproductive system is in the bone marrow. The female reproductive component is generated and derived from the bone marrow and its treatment leads to improve folliculogenesis, estradiol levels and symptoms like hot flush, depression, insomnia and panic disorder. Conclusion: It will be drawn after obtaining the results of the study.