Background: Acharya Sushrut, the ancient surgeon has included Bhagandar among the Ashtamahagad (8 dreadful diseases). The one which causes Bhag (vulva), Guda (anal region) and Basti Pradesh (urogenital area) Daran (cutting) are known as Bhagandar. As defined in modern science, this can be associated with Fistula in ano. Fistula in ano is an abnormal track in the perianal region with an external opening that interacts with the rectum or anal canal through a specific internal opening. Various modern surgical and medical treatments are trendy to manage Fistula in ano but there are certain limitations to all treatments. Aim and Objectives: ToStandardize Udumbar KsheerSutra and evaluates its clinical efficacy in comparison with Apamarga KsharSutra in the managing Bhagandar (Fistula in ano). Methodology: Standardization will be done by organoleptic and physicochemical testing of UdumbarKsheer and Udumbar KsheerSutra and then the standards of KsheerSutra will be determined. Total of 130 participants will be equally distributed in two groups with a minimum of 65 participants in each. In a group, A UdumbarKsheerSutraand in group B Apamarga KsharSutra will be changed after 7 days till the cure of fistula. Assessment of the patienswill be done on days 0, 15, 30, 45 and 60 and after the intervention, follow up will be taken on days 90 and 120. Results: Results will be drawn from the observations of objective parameters. Conclusion: Conclusion of the study will be drawn based on statistical data calculated from the collected data.