Introduction: Glial tumours account for 70% of all brain tumours with astrocytoma (38.7%) being the most frequent tumour. The prognosis of high-grade gliomas is very poor and have a limited overall survival rate. Aim: To establish the role of p53(immunohistochemical) with histopathological grades of various glial tumours such as astrocytoma, oligodendroglioma and ependymoma. Methods: This will be a Prospective analytical Study. The study will be carried out from 1st August 2018 to 31st July 2020 in the Histopathology division and Immunohistochemistry section in the Department of Pathology, Jawaharlal Nehru Medical College (J.N.M.C) in co-ordination with Department of Neuro-Surgery. A total of 50 resected specimens of radiologically suspected cases of Glial tumours operated in the Department of Neurosurgery will be considered for the study. The resected specimens will be grossed, processed and evaluated for histopathology and p53 expression. Results: A direct correlation between the histopathological grade and the p53 expression will be observed. Conclusion: High-grade gliomas exhibit high p53 expression. Thus, p53 as an adjunct to histological grade can provide a supportive clue to the clinicians to predict the biological behaviour of gliomas.