Background: Prediction of preeclampsia and instituting preventive measures in high-risk individuals will favourably affect pregnancy outcomes. Urinary calcium/creatinine ratio is a low-cost biochemical test for prediction of preeclampsia which has not been studied extensively especially in a rural setup. This study aims to evaluate its efficacy. Objectives: To study urinary calcium/creatinine ratio in pregnant women of rural setup and determine its association with preeclampsia to assess it as a screening stool for its prediction. Methods: This is a prospective observational study wherein 500 pregnant women will be recruited after informed consent before 20 weeks of gestation and urinary calcium creatinine ratio will be calculated from a spot sample. The study participants will then be followed up until their delivery to note the development of preeclampsia. A low ratio will be considered as a good predictor. Results: The researcher will note hypertensive disorders in study subjects and classify them according to severity. Mean urinary calcium creatinine ratio will be determined and the role of its spot value for predicting preeclampsia will be evaluated. A low value is expected in women with pre-eclampsia as compared to normotensive women. Conclusion: Depending on the study outcome, we would like to comment on the frequency of preeclampsia and the effectiveness of urinary calcium creatinine ratio in predicting it in a low resource setting.