This systematic review article focuses on the gamification design framework in supporting interaction skills among autism children. Generally, the fact that gamification is not a new phenomenon has attracted researchers to conduct several relevant studies. Unfortunately, previous studies were not targeting the interaction skills from the viewpoints of autism children. Thus, the present study reviewed a considerable amount of past literature on the mentioned viewpoints. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) was adopted for the review of the current research, which utilized four journal databases, namely IEEE, Springer, ScienceDirect and Google Scholar. Accordingly, the research effort resulted in a total of six articles that can be analyzed systematically. Significantly, the review managed to formulate three main themes, namely therapeutic, immersive and personalization. Finally, several recommendations were presented at the end of this research for future scholars__ampersandsignrsquo; reference.