Background: Dysmenorrhoea is a condition characterised by severe uterine pain during menstruation with a prevalence range between 50 to 87.8%. Many drugs have been tried to alleviate dysmenorrhea in women, but adverse events occur, therefore investigation of alternative treatments for dysmenorrhoea is warranted. The objective of this study is to compare the effect of Majoon Murmakki in dysmenorrhoea (usre tams). Materials and Methods: In a randomised standard controlled study, 45 patients of dysmenorrhea were randomly assigned to test (n=30) and control group (n=15). In test Majoon Murrmakki 3gm and control group mefenamic acid 500mg two times a day was given orally from 1st to 5th days of menstruation for two consecutive cycles. The primary outcome was assessed by subjective parameters viz. pain abdomen, nausea, vomiting, low backache diarrhoea fatigue and secondary outcome assessed by objective parameters viz. visual analogue scale for pain were assessed at each follow-up and improvement in the quality of life were assessed by SF-12 questionnaire before and after treatment. Results: Significant relief was observed in dysmenorrhoea and associated symptoms. 26 (89.7%) of the patients in test and 13 (100%) in the control group were relieved with p__ampersandsignlt;0.001 in subjective parameters as the primary outcome. 26 (89.7%) of the patients in test and 13 (100%) in the control group were relieved with p__ampersandsignlt;0.001 in objective parameters as the secondary outcome. Intergroup comparison shows no significant difference in improving subjective and objective parameters with p=1.00 and p=0.540 respectively. Conclusion: Majoon Murmakki is as effective as mefenamic acid in alleviating dysmenorrhea and associated symptoms.