Introduction: Functional condition of sympathy-adrenal system (SAS) and immune inflammation mediators in cases of metabolic syndrome (MS) has been studied. At the end of the 20th century, the concept of metabolic syndrome (MS) was proposed as a way to isolate a group of people who have several risk factors united by a single pathogenetic basis. MS belongs to the so-called __ampersandsignquot;diseases of civilization__ampersandsignquot; and is most common in economically developed countries. Method: 65 patients have been examined. Increased activity of SAS, especially noradrenalin (NE) and activation inflammatory cytokines - IL-6, TNF-a have been revealed. It has been determined that high activity of SAS leads to immune disbalance of humoral immunity which proved to be the marker of MS progressing. Result: When studying the daily excretion of catecolamines and DOPA in patients with arterial hypertension, a statistically significant increase in adrenaline (A) excretion was noted by 52.7% (p__ampersandsignlt;0.001), which is 2.1 times higher than the control group (p__ampersandsignlt;0.001). The highest indicators of the level of excretion A were observed in the group of patients with MS, which is 61.1% and, accordingly, 2.6 times higher than the control indicators. Conclusion: The high activity of SAS leads to an immuno-imbalance of humoral immunity, which play an important role in the pathogenesis of MS.