Activated charcoal, also referred to as medicoal is known to be a versatile tool in the field of Pharmaceutical Medicine. This was successfully prepared from the stem parts of Mangiferaindica (Mango), Psidiumguajava (Guava) and Perseagratissima (Avagado pear) by process of carbonization and thermal activation. Liquid phase study was conducted using Freundlich isotherm model to evaluate the equilibrium adsorption data generated for methylene blue (MB) sulphanephthalein dye stuff on activated medicoal test samples. Ultra violet spectroscopic method was used to assess the effect of variation of pH and temperatures on the adsorption profile of all the medical samples, including the commercially available standard. The results were found to be statistically significant using the one-tail analysis of variance (ANOVA) at confidence interval of p __ampersandsignle; 0.05. The research showed that the availability of negatively charged groups at the adsorbent surface is necessary for the adsorption of alkaline dye - stuff, thus the pH increase resulted to an increase in adsorption. The investigation also indicated that adsorption of locally sourced medicoal increases with temperature. The adsorption pattern of Perseagratissima compared favorably with that of the commercially available standard whereas Psidiumguajava ranked lowest.