Introduction: Low-grade inflammation is the basic pathophysiology in metabolic syndrome and the development of T2DM. Previous studies have demonstrated that increased neutrophil-lymphocyte ratio (NLR) is a marker of cardiovascular disease and cancer. Apart from many inflammatory markers, NLR is believed to be the balance between innate (neutrophils) and adaptive (lymphocytes) immune system responses to the low-grade inflammation. Methods: The present study was to find the relationship between NLR and hsCRP (High sensitive C reactive protein) in patients with T2DM in a tertiary care centre. Age and sex-matched 60 T2DM patients (males 32, female 28) were included in this study. After getting the written informed consent 5ml of fasting blood sample was collected for the analysis of fasting blood glucose, Total, differential WBC count and High sensitive Creative protein. Results: Our study showed that there is a strong positive correlation between increased NLR and hsCRP.357 (p__ampersandsignle; 0.005). Here, it is important to note that, males have low levels of hsCRP (2.63__ampersandsignplusmn;3.23) than females (4.82__ampersandsignplusmn;4.16) and these changes are also statistically significant (p__ampersandsignle; 0.026). Conclusion: The White blood cell count is one of the markers of subclinical inflammation. In diabetes, due to the presence of low-grade inflammation, the white cell count, NLR and hsCRP were increased. Hence, by assessing NLR, which is a simple clinical investigation will be useful in T2DM patients to control future vascular risk events.