Aim: This study aims to determine the comparison of interleukin-1__ampersandsignbeta; levels in preeclampsia pregnant women in large tribes in South and West Celebes. Method: This study used a cross-sectional design with case-control carried out in March to June 2020 in general hospital and Health centerTotoliMajene, general hospital Lasinrang, and Health center Matirobulu Pinrang, Elim Hospital, and Health center Rantepao Tana Toraja, Health center Bara Barayah and Jumpandang Baru in Makassar City. Respondents in this study were pregnant women__ampersandsigngt; 20 weeks divided into 2 groups: 44 pregnant women with preeclampsia and 44 pregnant women with normotension that met the criteria. The supporting data collected includes age, parity, body mass index (BMI) during pregnancy. Interleukin 1__ampersandsignbeta; levels were determined using the Human Interleukin 1__ampersandsignbeta; Elisa Kit with the ELISA method. Results: Differences in mean IL-1__ampersandsignbeta; levels in the preeclampsia group in four tribes (Bugis, Makassar, Mandar, and Toraja) with a significant value of p-value 0.002 (p __ampersandsignlt;0.05) as well as in the normotension group also had differences in IL-1__ampersandsignbeta; levels with a p-value of 0.003 (p __ampersandsignlt;0.05). Whereas the difference in IL-1__ampersandsignbeta; levels of preeclampsia and normotensive in each tribe results in a significant difference in Makassar (0.040) and Toraja (0.005) while the other 2 terms do not have significant IL-1__ampersandsignbeta; levels. Conclusion: There are differences in IL-1__ampersandsignbeta; levels between preeclampsia and normotension, and IL-1__ampersandsignbeta; levels can be influenced by tribal variations.