Introduction: Naga Parpam is being used as a medicine in Siddha, which is a Zinc Oxide based nanoparticle. Detailed analysis of Naga Parpam was done which shows Mg, Si and K as dopants. Photoluminescence study was also conducted which shows a peak at 649 nm. Aim and Objective: It is important to analyze due to which dopant this has occurred and hence two separate studies, Mg-doped ZnO and SiO2 doped ZnO were conducted. PL studies done on SiO2 doped ZnO shows significant peaks at 380nm and 649nm. Further, PL studies on Mg-doped ZnO shows a small peak at 381nm and two significant peaks at 640nm and 648nm. Result: Though the peak at 380nm is the characteristic peak for ZnO, when it is doped with Mg, the PL shows only a small peak. This shows the structural implications of the dopant and Match 3. XRD analysis showed secondary peaks for Naga Parpam and Mg-doped ZnO but not for SiO2 . Match 3 analysis showed SiO2 doped ZnO and ZnO has a hexagonal structure and Si has a cubic structure. In Naga Parpam, ZnO and Mg have a hexagonal while K and Si has a cubic structure. In the case of Mg-doped ZnO, both ZnO and Mg has a hexagonal structure. Hence in Si-doped ZnO, though there are two crystal systems hexagonal one and the other cubic, there are no secondary peaks observed in XRD, which has been established only from Match 3 analysis. But, in Mg-doped ZnO, it is observed that both ZnO and Mg has a hexagonal structure, from Match 3 analysis. PL analysis shows two sharp peaks at 640 nm and 648 nm and the characteristic peak of ZnO, which is the main constituent of the material is suppressed. Conclusion: It is concluded that when the dopant changes its characteristic structure to that of the bulk material, in PL analysis, the bulk material characteristics are suppressed. This may be the mechanism for mimicking the molecule and hence, this analysis may be a potential contender for drug delivery.